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sprague dawley rat red blood cells rbcs  (Innovative Research Inc)


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    Innovative Research Inc sprague dawley rat red blood cells rbcs
    Kaplan Meier and Dixon plot analysis of acute BDF toxicity. A, Adult male <t>Sprague</t> Dawley rats (about 300 gm) were administered 300 μg/kg BDF (p.o. in 500 μl saline by gavage). Survival was monitored for up to 7 days at which time all animals (n = 16) had died or had reached endpoint criteria.B, Adult male Sprague Dawley rats were administered the indicated doses of BDF (p.o. in 500 μl saline) after which survival was monitored up to 7 days. The x-axis “Trial” indicates each individual test that was done at the indicated BDF concentration. Dixon analysis yields the 4 day LD50 as 221 ± 14 μg/kg.
    Sprague Dawley Rat Red Blood Cells Rbcs, supplied by Innovative Research Inc, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rat+red+blood+cells+rbcs/Rat+Sprague+Dawley+Red+Blood+Cells/pmc05837443-170-2-12
    Average 90 stars, based on 2 article reviews
    sprague dawley rat red blood cells rbcs - by Bioz Stars, 2026-08
    90/100 stars

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    1) Product Images from "The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats"

    Article Title: The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats

    Journal: Toxicological Sciences

    doi: 10.1093/toxsci/kfx134

    Kaplan Meier and Dixon plot analysis of acute BDF toxicity. A, Adult male Sprague Dawley rats (about 300 gm) were administered 300 μg/kg BDF (p.o. in 500 μl saline by gavage). Survival was monitored for up to 7 days at which time all animals (n = 16) had died or had reached endpoint criteria.B, Adult male Sprague Dawley rats were administered the indicated doses of BDF (p.o. in 500 μl saline) after which survival was monitored up to 7 days. The x-axis “Trial” indicates each individual test that was done at the indicated BDF concentration. Dixon analysis yields the 4 day LD50 as 221 ± 14 μg/kg.
    Figure Legend Snippet: Kaplan Meier and Dixon plot analysis of acute BDF toxicity. A, Adult male Sprague Dawley rats (about 300 gm) were administered 300 μg/kg BDF (p.o. in 500 μl saline by gavage). Survival was monitored for up to 7 days at which time all animals (n = 16) had died or had reached endpoint criteria.B, Adult male Sprague Dawley rats were administered the indicated doses of BDF (p.o. in 500 μl saline) after which survival was monitored up to 7 days. The x-axis “Trial” indicates each individual test that was done at the indicated BDF concentration. Dixon analysis yields the 4 day LD50 as 221 ± 14 μg/kg.

    Techniques Used: Concentration Assay

    Effects of BDF on hematological properties. Adult male Sprague Dawley rats were administered 250 μg/kg (the oral LD50 dose) of BDF or the equivalent amount of vehicle. After 1 and 4 days, blood samples were taken for analysis of (A) hematocrit, (B) RBCs, (C) hemoglobin, and (D) PLT and MPV. Data are mean ± SEM of 4 rats per group (vehicle or BDF treated). *p < .05 versus corresponding vehicle group on the same day. E, Representative image of the small intramucossal hemorrhages that were observed in the BDF-treated rats upon necropsy. F, Hemolysis was measured after addition of the indicated concentrations of BDF or vehicle to packed RBCs. Comparison is made to addition of PBS alone. Data is mean ± SEM of n = 4 samples per group.
    Figure Legend Snippet: Effects of BDF on hematological properties. Adult male Sprague Dawley rats were administered 250 μg/kg (the oral LD50 dose) of BDF or the equivalent amount of vehicle. After 1 and 4 days, blood samples were taken for analysis of (A) hematocrit, (B) RBCs, (C) hemoglobin, and (D) PLT and MPV. Data are mean ± SEM of 4 rats per group (vehicle or BDF treated). *p < .05 versus corresponding vehicle group on the same day. E, Representative image of the small intramucossal hemorrhages that were observed in the BDF-treated rats upon necropsy. F, Hemolysis was measured after addition of the indicated concentrations of BDF or vehicle to packed RBCs. Comparison is made to addition of PBS alone. Data is mean ± SEM of n = 4 samples per group.

    Techniques Used:



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    Kaplan Meier and Dixon plot analysis of acute BDF toxicity. A, Adult male <t>Sprague</t> Dawley rats (about 300 gm) were administered 300 μg/kg BDF (p.o. in 500 μl saline by gavage). Survival was monitored for up to 7 days at which time all animals (n = 16) had died or had reached endpoint criteria.B, Adult male Sprague Dawley rats were administered the indicated doses of BDF (p.o. in 500 μl saline) after which survival was monitored up to 7 days. The x-axis “Trial” indicates each individual test that was done at the indicated BDF concentration. Dixon analysis yields the 4 day LD50 as 221 ± 14 μg/kg.
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    Kaplan Meier and Dixon plot analysis of acute BDF toxicity. A, Adult male Sprague Dawley rats (about 300 gm) were administered 300 μg/kg BDF (p.o. in 500 μl saline by gavage). Survival was monitored for up to 7 days at which time all animals (n = 16) had died or had reached endpoint criteria.B, Adult male Sprague Dawley rats were administered the indicated doses of BDF (p.o. in 500 μl saline) after which survival was monitored up to 7 days. The x-axis “Trial” indicates each individual test that was done at the indicated BDF concentration. Dixon analysis yields the 4 day LD50 as 221 ± 14 μg/kg.

    Journal: Toxicological Sciences

    Article Title: The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats

    doi: 10.1093/toxsci/kfx134

    Figure Lengend Snippet: Kaplan Meier and Dixon plot analysis of acute BDF toxicity. A, Adult male Sprague Dawley rats (about 300 gm) were administered 300 μg/kg BDF (p.o. in 500 μl saline by gavage). Survival was monitored for up to 7 days at which time all animals (n = 16) had died or had reached endpoint criteria.B, Adult male Sprague Dawley rats were administered the indicated doses of BDF (p.o. in 500 μl saline) after which survival was monitored up to 7 days. The x-axis “Trial” indicates each individual test that was done at the indicated BDF concentration. Dixon analysis yields the 4 day LD50 as 221 ± 14 μg/kg.

    Article Snippet: In brief, Sprague Dawley rat red blood cells (RBCs) were purchased from Innovative Research (Novi, Michigan) and kept at 4 °C.

    Techniques: Concentration Assay

    Effects of BDF on hematological properties. Adult male Sprague Dawley rats were administered 250 μg/kg (the oral LD50 dose) of BDF or the equivalent amount of vehicle. After 1 and 4 days, blood samples were taken for analysis of (A) hematocrit, (B) RBCs, (C) hemoglobin, and (D) PLT and MPV. Data are mean ± SEM of 4 rats per group (vehicle or BDF treated). *p < .05 versus corresponding vehicle group on the same day. E, Representative image of the small intramucossal hemorrhages that were observed in the BDF-treated rats upon necropsy. F, Hemolysis was measured after addition of the indicated concentrations of BDF or vehicle to packed RBCs. Comparison is made to addition of PBS alone. Data is mean ± SEM of n = 4 samples per group.

    Journal: Toxicological Sciences

    Article Title: The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats

    doi: 10.1093/toxsci/kfx134

    Figure Lengend Snippet: Effects of BDF on hematological properties. Adult male Sprague Dawley rats were administered 250 μg/kg (the oral LD50 dose) of BDF or the equivalent amount of vehicle. After 1 and 4 days, blood samples were taken for analysis of (A) hematocrit, (B) RBCs, (C) hemoglobin, and (D) PLT and MPV. Data are mean ± SEM of 4 rats per group (vehicle or BDF treated). *p < .05 versus corresponding vehicle group on the same day. E, Representative image of the small intramucossal hemorrhages that were observed in the BDF-treated rats upon necropsy. F, Hemolysis was measured after addition of the indicated concentrations of BDF or vehicle to packed RBCs. Comparison is made to addition of PBS alone. Data is mean ± SEM of n = 4 samples per group.

    Article Snippet: In brief, Sprague Dawley rat red blood cells (RBCs) were purchased from Innovative Research (Novi, Michigan) and kept at 4 °C.

    Techniques: